Table 1.
Subject Demographics, Pulmonary Function Tests, and Reproducibility of 129Xe CSSR ST and S/V Data.
| Demographics | PFT parameters | MRI measurements | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Age (sex) | FEV1 (% pred) | CV (%) | FEV1/FVC (% pred) | CV (%) | DLCO (% pred) | CV (%) | Mean ST (µm)a | CV (%) | Mean S/V (cm−1)a | CV (%) |
| HV1 | 24 (M) | 107.8 | — | 97.5 | — | — | — | 11.1 ± 0.3 | 2 | 286.7 ± 71.8 | 25 |
| HV1 | 32 (F) | 115.8 | — | 91.9 | — | — | — | 10.5 ± 0.5 | 5 | 259.9 ± 49.8 | 19 |
| HV1 | 42 (M) | 97.7 | — | 93.9 | — | — | — | 12.4 ± 0.7 | 5 | 237.7 ± 68.0 | 29 |
| HV1 | 63 (F) | 119.7 | — | 101.3 | — | — | — | 12.6 ± 0.6 | 5 | 171.8 ± 62.0 | 36 |
| HV1 | 28 (M) | 107.8 | — | 89.4 | — | — | — | 11.0 ± 0.4 | 3 | 186.3 ± 30.8 | 17 |
| HV1 | 31 (M) | 88.9 | — | 88.3 | — | — | — | 11.9 | — | 145.7 | — |
| HV2 | 59 (F) | 100.8 | — | 97.8 | — | — | — | 13.5 ± 0.4 | 3 | 164.2 ± 44.2 | 27 |
| HV2 | 55 (M) | 92.3 | — | 96.6 | — | — | — | 12.6 ± 0.3 | 3 | 238.6 ± 29.4 | 12 |
| HV2 | 63 (M) | 100.9 | — | 93.0 | — | — | — | 12.3 ± 0.7 | 6 | 154.7 ± 41.2 | 27 |
| HV2 | 58 (M) | 105.1 | — | 98.0 | — | — | — | 11.4 ± 0.6 | 5 | 261.8 ± 39.0 | 15 |
| HV2 | 58 (F) | 79.2 | — | 105.5 | — | — | — | 11.4 ± 0.4 | 4 | 180.4 ± 9.2 | 5 |
| HV2 | 62 (M) | 97.3 | — | 93.7 | — | — | — | 10.5 ± 0.1 | 1 | 185.5 ± 24.5 | 13 |
| HV2 | 40 (F) | 110.3 | — | 101.3 | — | — | — | 10.9 ± 0.6 | 5 | 84.4 ± 5.2 | 6 |
| HV2 | 54 (M) | 101.5 | — | 106.3 | — | — | — | 11.5 ± 0.3 | 3 | 322.8 ± 24.7 | 8 |
| HV2 | 66 (M) | 90.1 | — | 101.6 | — | — | — | 10.6 ± 0.7 | 7 | 155.9 ± 21.4 | 14 |
| COPD | 64 (F) | 31.5 ± 0.7 | 2 | 33.2 ± 0.6 | 2 | 33.2 ± 2.1 | 6 | 14.3 ± 1.8 | 12 | 70.9 ± 9.4 | 13 |
| COPD | 67 (F) | 45.4 ± 1.6 | 4 | 49.8 ± 0.7 | 1 | 98.4 ± 3.8 | 4 | 9.6 ± 0.3 | 3 | 215.8 ± 105.8 | 49 |
| COPD | 71 (M) | 31.0 ± 1.3 | 4 | 27.6 ± 1.1 | 4 | 13.6 ± 2.2 | 16 | 14.1 ± 1.2 | 9 | 75.5 ± 1.8 | 2 |
| COPD | 76 (M) | 43.5 ± 2.1 | 5 | 32.5 ± 0.8 | 3 | 29.6 ± 2.0 | 7 | 16.5 ± 0.3 | 2 | 90.5 ± 2.2 | 2 |
| COPD | 59 (F) | 38.6 ± 2.5 | 6 | 42.8 ± 0.8 | 2 | 38.0 ± 4.1 | 11 | 15.7 ± 0.6 | 4 | 130.0 ± 29.9 | 23 |
HV1, healthy volunteers recruited for preliminary investigations; HV2, age‐matched healthy volunteers recruited for reproducibility tests; COPD, patients with chronic obstructive pulmonary disease recruited for reproducibility tests; PFT, pulmonary function test; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; DLCO, diffusing capacity of carbon monoxide; ST, septal thickness; S/V, surface‐area‐to‐volume ratio; CV, coefficient of variation; % pred, pulmonary functional parameters expressed as a percentage of a predicted value, based on demographic factors such as age and height.
All values derived from scans at FRC + 1 L using the multi‐sweep sequence.