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. 2017 Feb 17;115(6):647–662. doi: 10.1002/jso.24561

Table 3.

Summary of discussed validation studies with assigned Simon Hayes level of evidence

Assay Focus Study Setting Pre‐menopausal Post‐menopausal ER+ ER− LN+ LN− Simon category
Blue print
Prognostic
Krijgsman Breast Cancer Res Treat 2011 Various D
Breast Cancer Index
Prognostic
Goetz Clin Cancer Res 2006 AET B
Jerevall Br J Cancer 2011 AET B
Sgroi Breast Cancer Res 2016 AET B
Prognostic and predictive
Sgroi Lancet Oncol 2013 AET B
Zhang Clin Cancer Res 2013 AET B
Endopredict
Prognostic
Filipits Clin Cancer Res 2011 AET B
Dubsky Ann Oncol 2013 AET B
Martin Breast Cancer Res 2014 AET/ACT B
Buus J Natl Cancer Inst 2016 AET B
IHC4
Prognostic
Cuzick J Clin Oncol 2011 AET B
Park Oncology 2014 AET/ACT C
Sgroi Lancet Oncol 2013 AET B
Stephen Br J Cancer 2014 AET B
MammaPrint
Prognostic
Bueno‐de‐Mesquita Lancet Oncol 2007 AET/ACT D
Buyse J Natl Cancer Inst 2006 No Rx C
Cardoso N Engl J Med 2016 AET/ACT A
Mook Ann Oncol 2010 AET D
Mook Breast Cancer Res Treat 2009 AET/ACT D
van de Vijver N Engl J Med 2002 AET/ACT D
Wittner Clin Cancer Res 2008 AET/ACT D
Predictive
Knauer Breast Cancer Res Treat 2010 ACT D
Oncotype
Prognostic
Dowsett J Clin Oncol 2010 AET B
Paik N Engl J Med 2004 AET B
Sparano N Engl J Med 2015 AET A
Gluz J Clin Oncol 2016 AET A
Prognostic and predictive
Albain Lancet Oncol 2010 AET/ACT B
Predictive
Paik J Clin Oncol 2006 AET/ACT B
PAM50
Prognostic
Chia Clin Cancer Res 2012 AET B
Dowsett J Clin Oncol 2013 AET B
Gnant Ann Oncol 2014 AET B
Gnant Ann Oncol 2015 AET B
Predictive
Cheang Clin Cancer Res 2012 ACT B
Liu Breast Cancer Res Treat 2015 ACT B

AET, adjuvant ETx; ACT, adjuvant CTx; ER+, estrogen receptor positive; ER−, estrogen receptor negative; LN+, lymph node positive; LN−, lymph node negative; LOE, level of evidence (Simon J Natl Cancer Inst 2009).