Figure 2.

The Vps13F family. (a) Proteins of the vacuolar protein sorting 13 family share a similar domain organization. On the basis of primary sequence analysis, Dictyostelium proteins share the same six conserved domains present in human and yeast proteins: two N‐terminal domains (the first one corresponding to the Chorein domain), a repeated coiled region, an SHR‐binding domain, and two C‐terminal domains (the last one corresponding to an autophagy or Atg2‐related domain). (b) Unrooted maximum‐likelihood phylogenetic tree of Vps13F proteins from dictyostelid, fungi, and metazoan species. Numbers at the nodes indicate the percentage of bootstrap support (upper values for the maximum‐likelihood tree and lower values for the neighbor‐joining tree; only numbers above 50% are shown)