Table 3.
Characteristic | Number (%) of cases | Number (%) of controls | Unadjusted OR (95% CI) | Adjusteda OR (95% CI) |
---|---|---|---|---|
Cardiac disease | ||||
No | 94 (93.1) | 710 (98.9) | 1 | 1 |
Yes | 7 (6.9) | 8 (1.1) | 6.61 (2.34–18.64) | 9.98 (3.29–30.23) |
Pre‐existing diabetes mellitus (Type 1 & 2) | ||||
No | 97 (96.0) | 714 (99.4) | 1 | 1 |
Yes | 4 (4.0) | 4 (0.6) | 7.36 (1.81–29.91) | 5.04 (0.86–29.61) |
Essential hypertension | ||||
No | 92 (91.1) | 711 (99) | 1 | 1 |
Yes | 9 (8.9) | 7 (1.0) | 9.94 (3.61–27.32) | 6.44 (2.14–19.35) |
Haematological disorders | ||||
No | 92 (91.1) | 704 (98.1) | 1 | 1 |
Yes | 9 (8.9) | 14 (1.9) | 4.92 (2.07–11.68) | 2.48 (0.87–7.09) |
Prior thrombotic event | ||||
No | 98 (97.0) | 715 (99.6) | 1 | 1 |
Yes | 3 (3.0) | 3 (0.4) | 7.30 (1.45–36.65) | 3.28 (0.42–25.72) |
Inflammatory conditions | ||||
No | 82 (81.2) | 716 (99.7) | 1 | 1 |
Yes | 19 (18.8) | 2 (0.3) | 82.95 (18.98–362.52) | 65.05 (14.28–296.37) |
Musculoskeletal disorders | ||||
No | 92 (91.1) | 717 (99.9) | 1 | 1 |
Yes | 9 (8.9) | 1 (0.1) | 70.14 (8.79– 559.96) | 63.10 (7.48– 532.36) |
Asthma | ||||
No | 92 (91.1) | 692 (96.4) | 1 | 1 |
Yes | 9 (8.9) | 26 (3.6) | 2.60 (1.18–5.73) | 2.72 (1.14–6.46) |
Epilepsy | ||||
No | 100 (99) | 714 (99.4) | 1 | |
Yes | 1 (1) | 4 (0.6) | 1.79 (0.20–16.13) | Excluded |
Mental health problems | ||||
No | 83 (82.2) | 689 (96) | 1 | 1 |
Yes | 18 (17.8) | 29 (4) | 5.15 (2.74–9.68) | 3.27 (1.53–7.01) |
Neurological conditions | ||||
No | 95 (94.1) | 717 (99.9) | 1 | 1 |
Yes | 6 (5.9) | 1 (0.1) | 45.28 (5.39–380.22) | 17.84 (1.80–177.12) |
Infection | ||||
No | 93 (92.1) | 713 (99.3) | 1 | 1 |
Yes | 8 (7.9) | 5 (0.7) | 12.27 (3.93–38.28) | 11.49 (3.26–40.47) |
95% CI, 95% confidence intervals; OR, odds ratio.
Missing data in pre‐existing medical problem, n = 52.
See Appendix S1 for more information on included conditions.
Each pre‐existing medical problem was modelled separately in the main model using complete case analysis.
Adjusted for age, smoking status, previous pregnancy problem and inadequate use of antenatal care.