Table 3.
Exploratory analysis examining pre‐existing medical conditions associated with maternal mortality at advanced maternal age
| Characteristic | Number (%) of cases | Number (%) of controls | Unadjusted OR (95% CI) | Adjusteda OR (95% CI) |
|---|---|---|---|---|
| Cardiac disease | ||||
| No | 94 (93.1) | 710 (98.9) | 1 | 1 |
| Yes | 7 (6.9) | 8 (1.1) | 6.61 (2.34–18.64) | 9.98 (3.29–30.23) |
| Pre‐existing diabetes mellitus (Type 1 & 2) | ||||
| No | 97 (96.0) | 714 (99.4) | 1 | 1 |
| Yes | 4 (4.0) | 4 (0.6) | 7.36 (1.81–29.91) | 5.04 (0.86–29.61) |
| Essential hypertension | ||||
| No | 92 (91.1) | 711 (99) | 1 | 1 |
| Yes | 9 (8.9) | 7 (1.0) | 9.94 (3.61–27.32) | 6.44 (2.14–19.35) |
| Haematological disorders | ||||
| No | 92 (91.1) | 704 (98.1) | 1 | 1 |
| Yes | 9 (8.9) | 14 (1.9) | 4.92 (2.07–11.68) | 2.48 (0.87–7.09) |
| Prior thrombotic event | ||||
| No | 98 (97.0) | 715 (99.6) | 1 | 1 |
| Yes | 3 (3.0) | 3 (0.4) | 7.30 (1.45–36.65) | 3.28 (0.42–25.72) |
| Inflammatory conditions | ||||
| No | 82 (81.2) | 716 (99.7) | 1 | 1 |
| Yes | 19 (18.8) | 2 (0.3) | 82.95 (18.98–362.52) | 65.05 (14.28–296.37) |
| Musculoskeletal disorders | ||||
| No | 92 (91.1) | 717 (99.9) | 1 | 1 |
| Yes | 9 (8.9) | 1 (0.1) | 70.14 (8.79– 559.96) | 63.10 (7.48– 532.36) |
| Asthma | ||||
| No | 92 (91.1) | 692 (96.4) | 1 | 1 |
| Yes | 9 (8.9) | 26 (3.6) | 2.60 (1.18–5.73) | 2.72 (1.14–6.46) |
| Epilepsy | ||||
| No | 100 (99) | 714 (99.4) | 1 | |
| Yes | 1 (1) | 4 (0.6) | 1.79 (0.20–16.13) | Excluded |
| Mental health problems | ||||
| No | 83 (82.2) | 689 (96) | 1 | 1 |
| Yes | 18 (17.8) | 29 (4) | 5.15 (2.74–9.68) | 3.27 (1.53–7.01) |
| Neurological conditions | ||||
| No | 95 (94.1) | 717 (99.9) | 1 | 1 |
| Yes | 6 (5.9) | 1 (0.1) | 45.28 (5.39–380.22) | 17.84 (1.80–177.12) |
| Infection | ||||
| No | 93 (92.1) | 713 (99.3) | 1 | 1 |
| Yes | 8 (7.9) | 5 (0.7) | 12.27 (3.93–38.28) | 11.49 (3.26–40.47) |
95% CI, 95% confidence intervals; OR, odds ratio.
Missing data in pre‐existing medical problem, n = 52.
See Appendix S1 for more information on included conditions.
Each pre‐existing medical problem was modelled separately in the main model using complete case analysis.
a
Adjusted for age, smoking status, previous pregnancy problem and inadequate use of antenatal care.