Table 3.

Event rates in drug exposure categories including methadone, hydromorphone, morphine and fentanyl. All opioid doses are adjusted and reported as their equivalent in oral methadone.

	Methadone			Hydromorphone
	Days Exposed	% Days With Hypoglycemia	95% CI	Days Exposed	% Days With Hypoglycemia	95% CI
Oral 0-15 mg equivalent	1033	3.9	(2.9-5.2)	1103	3.8	(2.8-5.1)
Oral 15-40 mg equivalent	1883	4.2	(3.4-5.2)	72	4.2	(1.4-11.5)
Oral 40-80 mg equivalent	1827	7.4	(6.3-8.7)	0
Oral > 80 equivalent	1761	8.0	(6.8-9.3)	1	0.0	(0.0-94.9)
IV 0-15 mg equivalent	314	5.7	(3.7-8.9)	1995	5.0	(4.1-6.1)
IV 15-40 mg equivalent	498	5.6	(3.9-8.0)	562	5.2	(3.6-7.3)
IV 40-80 mg equivalent	349	12.6	(9.5-16.5)	188	6.4	(3.7-10.8)
IV > 80 mg equivalent	345	13.0	(9.9-17.0)	106	2.8	(1.0-8.0)
PCA	542	16.4	(13.5-19.8)	2375	4.7	(3.9-5.6)
	Morphine			Fentanyl
	Days Exposed	% Days With Hypoglycemia	95% CI	Days Exposed	% Days With Hypoglycemia	95% CI
Oral 0-15 mg equivalent	297	5.1	(3.1-8.2)	0
Oral 15-40 mg equivalent	56	1.8	(0.1-9.4)	1	0.0	(0.0-94.9)
Oral 40-80 mg equivalent	37	0.0	(0.0-9.4)	6	0.0	(0.0-39.0)
Oral > 80 equivalent	43	0.0	(0.0-8.2)	27	3.7	(0.2-18.3)
IV 0-15 mg equivalent	710	5.1	(3.7-6.9)	102	7.8	(4.0-14.7)
IV 15-40 mg equivalent	33	18.2	(8.6-34.4)	227	4.8	(2.7-8.5)
IV 40-80 mg equivalent	2	0.0	(0.0-65.8)	345	2.0	(1.0-4.1)
IV > 80 mg equivalent	0			948	2.8	(2.0-4.1)
PCA	575	5.2	(3.7-7.4)	2241	3.1	(2.4-3.9)
Transdermal				1236	2.3	(1.6-3.3)