Table 1.
Fasting plasma concentration of pro-neurotensin (pro-NT) in relation to obesity, insulin resistance and incidence of new-onset obesity in human subjects (Malmö Diet and Cancer Cardiovascular Cohort, MDC-CC)
| N total / N Cases | Odds ratio (95% confidence interval) | p for trend | ||||
|---|---|---|---|---|---|---|
| Pro-NT Quartile 1 | Pro-NT Quartile 2 | Pro-NT Quartile 3 | Pro-NT Quartile 4 | |||
| Prevalent obesity | 4626 / 604 | 1.0 (ref) | 1.00 (0.78–1.29) | 1.13 (0.88–1.45) | 1.34 (1.05–1.70) | 0.01 |
| Prevalent abdominal obesity | 4625 / 1769 | 1.0 (ref) | 1.07 (0.90–1.27) | 1.23 (1.04–1.46) | 1.30 (1.09–1.54) | 0.001 |
| Prevalent insulin resistance | 4468 / 1140 | 1.0 (ref) | 1.30 (1.06–1.59) | 1.43 (1.17–1.74) | 1.70 (1.39–2.06) | <0.0001 |
| New-onset obesity | 2594 / 333 | 1.0 (ref) | 1.41 (0.95–2.10) | 1.79 (1.21–2.65) | 2.05 (1.38–3.06) | <0.0001 |
N total / N cases denotes total number of subjects in the analysis divided by the number of cases with listed obesity or insulin resistance phenotype. Pro-NT Quartiles 1–4 define the MDC-CC population quartiles (lowest to highest) with median (range) baseline fasting plasma pro-NT concentrations (pmol/L) of 60.1 (3.3–75.9), 89.3 (75.9–105), 123 (105–149) and 190 (149–1155), respectively. Data are presented as odds ratios (95% confidence intervals), and subjects belonging to the lowest quartile of pro-NT were defined as the reference group (odds ratio =1). p for trend denotes the p-value for linear trend over quartiles 1–4. Logistic regression models were used for comparisons between quartiles and linear trends over quartiles (see Methods).