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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Mol Genet Metab. 2017 Apr 6;121(2):96–103. doi: 10.1016/j.ymgme.2017.04.003

Figure 4.

Figure 4

Metabolomics analysis of Trp which is primarily metabolized by the kynurenine pathway or converted to serotonin in the gastrointestinal tract. Values are mean ± SE scaled intensity for metabolites of Trp in plasma from 18 PKU subjects consuming a low-Phe diet in combination with AA-MF or GMP-MF. Levels of quinolinic acid in urine are shown. Compounds within dashed lines are synthesized by intestinal microbes, either exclusively or in combination with human metabolism.