TABLE 6.

HVR-1 genetic parameters on treatment in patients with different therapeutic responses

Sample	Genotype	Daya	RNA	No.	Complexity		Intersample analysisb (SD)				Intrasample analysisc				Responsed
					Nucleotide	Amino acid	d	dS	dN	dN/dS	d	dS	dN	dN/dS	EVR	SVR
LIV14	1a	−30	3.79E+05	12	0.697	0.635	0.110 (0.027)	0.043 (0.027)	0.141 (0.033)	3.28	0.110	0.043	0.141	3.28	N	N
		150	4.76E+05	13	0.693	0.693	0.131 (0.029)	0.026 (0.017)	0.177 (0.046)	6.81	0.138	0.039	0.181	4.64
LIV15	1a	−30	4.16E+05	12	0.779	0.703	0.063 (0.017)	0.044 (0.020)	0.071 (0.023)	1.61	0.063	0.044	0.071	1.61	N	N
		150	2.50E+05	12	0.450	0.000	0.010 (0.006)	0.043 (0.026)	0.000 (0.000)	0.00	0.063	0.142	0.040	0.28
LIV16	1a	−30	3.67E+05	11	0.737	0.737	0.114 (0.024)	0.087 (0.034)	0.126 (0.034)	1.45	0.114	0.087	0.126	1.45	N	N
		90	5.70E+05	14	0.376	0.376	0.027 (0.011)	0.000 (0.000)	0.037 (0.016)	NAe	0.095	0.057	0.109	1.91
		270	5.57E+05	12	0.668	0.331	0.033 (0.013)	0.054 (0.027)	0.026 (0.014)	0.48	0.177	0.213	0.165	0.77
LIV18	1a	−30	3.72E+05	12	0.796	0.607	0.076 (0.021)	0.078 (0.041)	0.075 (0.027)	0.96	0.076	0.078	0.075	0.96	C	N
		29	3.30E+04	10	0.473	0.473	0.133 (0.031)	0.150 (0.058)	0.128 (0.042)	0.85	0.129	0.153	0.123	0.80
		60	3.34E+02	12	0.432	0.432	0.123 (0.032)	0.175 (0.082)	0.106 (0.028)	0.61	0.163	0.256	0.135	0.53
LIV04	1a	−30	5.70E+05	12	0.115	0.115	0.004 (0.003)	0.000 (0.000)	0.006 (0.004)	NA	0.004	0.000	0.006	NA	C	C
		15	1.38E+03	13	0.917	0.761	0.050 (0.016)	0.033 (0.019)	0.058 (0.020)	1.76	0.035	0.017	0.043	2.53
LIV12	1a	−30	2.44E+05	13	0.592	0.592	0.018 (0.008)	0.007 (0.007)	0.023 (0.012)	3.29	0.018	0.007	0.023	3.29	C	C
		1	2.50E+04	12	0.442	0.115	0.010 (0.005)	0.025 (0.014)	0.006 (0.004)	0.24	0.228	0.065	0.296	4.55
		7	1.49E+02	11	0.127	0.127	0.002 (0.002)	0.000 (0.000)	0.003 (0.003)	NA	0.225	0.053	0.298	5.63
LIV02	1a	−30	1.40E+05	10	0.141	0.000	0.002 (0.003)	0.011 (0.012)	0.000 (0.000)	0.00	0.002	0.011	0.000	0.00	C	N
		3	3.62E+04	13	0.308	0.308	0.147 (0.032)	0.061 (0.045)	0.181 (0.060)	2.97	0.094	0.045	0.113	2.51
		29	8.46E+02	13	0.309	0.209	0.007 (0.005)	0.014 (0.017)	0.005 (0.004)	0.36	0.356	0.166	0.430	2.59

^aDay indicates treatment day when the serum sample for RNA load and quasispecies testing was drawn.

^bValues for individual baseline and follow-up samples.

^cValues for composite of baseline and follow-up samples.

^dC, a response was achieved; N, a response was not achieved.

^eNA, not applicable.