Table 1.
Disease-Specific Chemotherapy Regimens for Pediatric Lymphomas at Kamuzu Central Hospital.a
| Lymphoma | Protocol | Number of Cycles | Frequency |
|---|---|---|---|
| Stage I/II | Modified INCTR 03-06 protocol | 6 | 14 Days |
| Burkitt lymphoma | Cyclophosphamide 1200 mg/m2 ×1 | ||
| Vincristine 1.4 mg/m2 ×1 | |||
| Methotrexate 75 mg/m2 ×1 | |||
| Prednisone 1-2 mg/kg/d ×5 | |||
| DLBCL and | Modified CHOP protocolb | 6 | 21 Days |
| Stage III/IV | Cyclophosphamide 800 mg/m2 ×1 | ||
| Burkitt lymphoma | Doxorubicin 40 mg/m2 ×1 | ||
| Vincristine 2 mg/m2 ×1 | |||
| Prednisone 1-2 mg/kg/d ×5 | |||
| Lymphoblastic | Modified CHOP protocolb | 8 | 21 Days |
| Lymphoma | Cyclophosphamide 800 mg/m2 ×1 | ||
| Doxorubicin 40 mg/m2 ×1 | |||
| Vincristine 2 mg/m2 ×1 | |||
| Prednisone 1-2 mg/kg/d ×5 | |||
| Hodgkin | Modified ABVE-PC protocol | 6-8 | 21 Days |
| Lymphoma | Doxorubicin 40 mg/m2 ×1 | ||
| Bleomycin 10 U/m2 ×1 | |||
| Vincristine 2 mg/m2 ×1 | |||
| Etoposide unavailable | |||
| Cyclophosphamide 800 mg/m2 ×1 | |||
| Prednisone 1-2 mg/kg/d ×5 |
Abbreviations: INCTR, International Network for Cancer Treatment and Research; DLBCL, diffuse large B-cell lymphoma; CHOP, cyclophosphamide, doxorubicin, vincristine, prednisone.
a
All patients with non-Hodgkin lymphoma received intrathecal methotrexate plus hydrocortisone—2 doses per cycle for patients with central nervous system involvement and 1 dose per cycle otherwise.
b
An initial 1-week COP reduction prephase (cyclophosphamide 300-400 mg/m2, vincristine 2 mg/m2, prednisone 1-2 mg/kg for 5 days) was given to mitigate risk for tumor lysis syndrome.