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Grade 3–4 adverse reactions.
| Toxicity | Nanoliposomal irinotecan + 5-fluorouracil/leucovorin (n = 117) |
5-fluorouracil/leucovorin
(n = 134) |
||
|---|---|---|---|---|
| Any grade | Grades 3–4 | Any grade | Grades 3–4 | |
| Diarrhea | 69 (59) | 15 (13) | 35 (26) | 6 (4) |
| Vomiting | 61 (52) | 13 (11) | 35 (26) | 4 (3) |
| Nausea | 60 (51) | 9 (8) | 46 (34) | 4 (3) |
| Fatigue | 47 (40) | 16 (14) | 37 (28) | 5 (4) |
| Neutropenia† | 46 (39) | 32 (27) | 7 (5) | 2 (1) |
| Anemia | 44 (38) | 11 (9) | 31 (23) | 9 (7) |
