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. 2017 Jun 26;12(6):e0177472. doi: 10.1371/journal.pone.0177472

Fig 1. Lack of endogenous Gal-8 expression exacerbates EAE.

Fig 1

Lgals8+/+ (WT) and Lgals8-/- (Gal-8 KO) immunized with MOGp. (A) Clinical scores monitored daily for 25 days show an exacerbated EAE in Gal-8 KO mice (***p<0.001; Mann Whitney; day by day clinical Score comparisons; n = 20 WT; n = 22 Gal-8 KO). (B) Spinal cord histopathological analysis after 10 days of immunization show enhanced immune cell infiltration and demyelination in Gal-8 KO mice, shown by H&E staining (I and II) and luxol fast blue staining (III and IV). Scale bar = 50 μm.