TABLE 3.
Ex vivo CD8 T-cell responses against autologous fibroblasts infected with recombinant MVAs
| MVA expressing: | % IFN-γ staining of total CD8 T cells for donora:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| CMV seropositive
|
CMV seronegative
|
||||||||
| 1 | 2 | 3 | 4 | 6 | 7 | 9 | 10 | 12 | |
| IE-1 | 1.39 | 6.83 | 1.6 | 0.97 | 1.37 | 4.8 | 0.19 | 0 | 0 |
| IE-2 | 0 | 0.48 | 0 | 0.07 | 0 | 0.05 | 0 | 0 | 0.07 |
| pp50 | 0.79 | 3.33 | 1.41 | 0.27 | 4.15 | 0.75 | 0 | 0 | 0 |
| pp65 | 1.79 | 0.29 | 1.46 | 0.67 | 2.21 | 2.75 | 3.19 | 0.08 | 0.06 |
| pp150 | 0 | 0.03 | 0 | 0 | 0.4 | 0 | 0 | 0 | 0 |
| gB | 0.25 | 0.21 | 0.12 | 0 | 1.3 | 0.22 | 0.14 | 0.04 | 0.03 |
| Total | 4.22 | 11.2 | 4.59 | 1.98 | 9.45 | 8.57 | 3.55 | 0.18 | 0.16 |
| RV798 | 4.1 | 9.2 | 12.8 | 2.64 | 6.62 | 5.7 | 6.8 | 0.09 | 0.13 |
a
Total responses shown are the sum of protein-specific responses (after subtracting the background response (control MVA) from each recombinant MVA response).