Table 1.
Demographics
| Parameter | No use of amiodarone before HTX (n=412) | Acute use of amiodarone before HTX (n=23) | Chronic use of amiodarone before HTX (n=95) | P-value |
|---|---|---|---|---|
| Recipient data | ||||
| Age (years), mean ± SD | 51.6±10.8 | 51.5±9.2 | 52.6±9.0 | 0.7037 |
| Male sex, n (%) | 317 (76.9%) | 19 (82.6%) | 76 (80.0%) | 0.6883 |
| BMI (kg/m2), mean ± SD | 24.7±3.9 | 24.4±3.5 | 25.3±3.6 | 0.3807 |
| CAD, n (%) | 168 (40.8%) | 10 (43.5%) | 44 (46.3%) | 0.6071 |
| Arterial hypertension, n (%) | 218 (52.9%) | 13 (56.5%) | 57 (60.0%) | 0.4473 |
| Dyslipidemia, n (%) | 257 (62.4%) | 14 (60.9%) | 68 (71.6%) | 0.2305 |
| Diabetes mellitus, n (%) | 140 (34.0%) | 8 (34.7%) | 34 (35.8%) | 0.9445 |
| Renal insufficiency,^ n (%) | 230 (55.8%) | 14 (60.9%) | 61 (64.2%) | 0.3118 |
| Principal diagnosis for HTX | ||||
| Nonischemic CMP, n (%) | 212 (51.5%) | 13 (56.5%) | 59 (62.1%) | 0.1650 |
| Ischemic CMP, n (%) | 138 (33.5%) | 8 (34.7%) | 35 (36.8%) | 0.8233 |
| Valvular heart disease, n (%) | 28 (6.8%) | 1 (4.4%) | 0 (0.0%) | 0.0309* |
| Cardiac amyloidosis, n (%) | 34 (8.2%) | 1 (4.4%) | 1 (1.1%) | 0.0379* |
| Donor data | ||||
| Age (years), mean ± SD | 39.5±13.4 | 42.0±12.1 | 39.6±12.8 | 0.6796 |
| Male sex, n (%) | 187 (45.4%) | 11 (47.8%) | 39 (41.1%) | 0.7114 |
| BMI (kg/m2), mean ± SD | 24.5±4.0 | 24.0±1.8 | 25.0±4.2 | 0.4124 |
| Transplant sex mismatch | ||||
| Mismatch, n (%) | 174 (42.2%) | 10 (43.5%) | 45 (47.4%) | 0.6602 |
| Donor (m) to recipient (f), n (%) | 22 (5.3%) | 1 (4.4%) | 4 (4.2%) | 0.8908 |
| Donor (f) to recipient (m), n (%) | 152 (36.9%) | 9 (39.1%) | 41 (43.2%) | 0.5233 |
| Perioperative data | ||||
| Biatrial HTX, n (%) | 129 (31.3%) | 4 (17.4%) | 28 (29.5%) | 0.3605 |
| Bicaval HTX, n (%) | 96 (23.3%) | 4 (17.4%) | 15 (15.8%) | 0.2434 |
| Total orthotopic HTX, n (%) | 187 (45.4%) | 15 (65.2%) | 52 (54.7%) | 0.0613 |
| Ischemic time, (min), mean ± SD | 212.2±64.8 | 215.9±66.8 | 207.1±66.6 | 0.7482 |
| Ischemic time ≥240 min, n (%) | 135 (32.8%) | 9 (39.1%) | 31 (32.6%) | 0.8160 |
| LOS (days), mean ± SD | 42.0±21.4 | 47.7±27.0 | 46.3±26.0 | 0.1475 |
Notes:
^
Glomerular filtration rate <60 mL/min/1.73 m2.
*
Statistically significant (P<0.05).
Abbreviations: HTX, heart transplantation; BMI, body mass index; CAD, coronary artery disease; CMP, cardiomyopathy; m, male; f, female; LOS, length of initial hospital stay; SD, standard deviation.