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. 2017 Jun 21;11:71–79. doi: 10.2147/BTT.S134920

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© 2017 Yang et al. This work is published and licensed by Dove Medical Press Limited

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Beclin 1 is critical for maintaining the proliferation of breast cancer stem cells (CSCs) and progenitor cells. (A) Western blot detected the effect of Beclin 1 knockout on pluripotency-associated (PA) expression of HeLa cells. (B and C) Detection of HeLa formation. Wild-type and Beclin 1^−/− HeLa cells were cultured in CSC culture media for about 10–12 days; the number and size of tumorsphere were calculated (B). The numbers are shown in the histogram (C). (D) The effect of Beclin 1 knockout on HeLa CSCs differentiation. When cultured in adipogenic induction media for about 2 weeks, there were more lipid droplet-like cells in the Beclin 1^−/− group. Magnification ×100.