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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2016 Dec 9;25(3):838–846. doi: 10.1016/j.bmc.2016.11.035

Fig. 1.

Fig. 1

X-ray co-crystal structure of TAK1-1 (yellow stick-cyan ribbon) (PDB 5J9L) overlaid with TAK1-2 (purple stick-green ribbon) (PDB 5J8I). (A) TAK1-2 covalently binds to Cys174 and (B) hydrogen bonds (blue dashes) extend between the anilinopyrimidine moiety of 1 or 2 and the hinge region of TAK1.