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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2016 Dec 9;25(3):838–846. doi: 10.1016/j.bmc.2016.11.035

Fig. 2.

Fig. 2

(A) X-ray co-crystal structures of TAK1-2 (green, PDB 5J8I) overlaid with TAK1-10 (orange, PDB 5E7R) showing interactions between the oxygen linkage for warhead and Asn161 (blue dashes). (B) X-ray co-crystal structures of TAK1-5 (cyan, PDB 5J7S) and TAK1-7 (gray, PDB 5JH6). Nitrogen linkage results in loss of interactions with Asn161.