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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2016 Dec 9;25(3):838–846. doi: 10.1016/j.bmc.2016.11.035

Scheme 1.

Scheme 1

Structures of WZ4002, 1 and 2 (A) and synthesis of 2 (B). Reagents and conditions: i) K2CO3, DMSO, RT; ii) TFA, 2-BuOH, 100 °C; iii) Raney nickel, H2, MeOH; iv) acryloyl chloride, sat. NaHCO3, THF, 0 °C ~RT.