Table 1.
Oxidative damage to DNA, lipids, and proteins in the rat brains with implants of unlabeled (0), SPION-labeled, or CZF-labeled rat mesenchymal stem cells
| Interval | rMSC labeling | DNA damage tail DNA (%)
|
Lipid peroxidation 15-F2t-isoprostane (pg/mL)
|
Protein oxidation carbonyl groups (nmol/mg)
|
|||
|---|---|---|---|---|---|---|---|
| Mean ± SD | P-value | Mean ± SD | P-value | Mean ± SD | P-value | ||
| 24 hours | 0 | 20.10±4.10 | 51.52±15.71 | 5.48±0.22 | |||
| SPION | 25.94±3.94 | 0.2149 | 52.64±4.83 | 0.8278 | 4.99±0.68 | 0.0539 | |
| CZF | 29.13±6.39 | 0.1699 | 39.73±6.01 | 0.3487 | 5.30±0.33 | 0.2928 | |
| 4 weeks | 0 | 22.98±2.38 | 41.33±7.98 | 5.30±0.14 | |||
| SPION | 22.35±1.82 | 0.7576 | 45.97±6.23 | 0.6611 | 5.40±0.33 | 0.7058 | |
| CZF | 18.23±1.99 | 0.0557 | 49.58±7.33 | 0.4093 | 5.50±0.22 | 0.1723 | |
Abbreviations: SD, standard deviation; CZF, cobalt-zinc-ferrite; SPION, superparamagnetic iron oxide nanoparticle; rMSC, rat mesenchymal stem cell.