Figure 1.

Effect of treatment with α-bis-LNCs in pulmonary elastance and airway hyperresponsiveness induced by LPS.

Notes: The animals were pretreated orally with α-bis, α-bis-LNCs (30, 50, or 100 mg kg⁻¹), or ULNCs. After 4 hours, the mice were anesthetized and challenged intranasally with LPS (25 μg/25 μL) or vehicle. Airway responsiveness was measured by changes in airway elastance after aerosolization of methacholine 18 hours after LPS instillation. Data are expressed as the mean ± SEM (n=5–7). ⁺P<0.05 compared with the saline group; *P<0.05 compared with the LPS-induced group; ^§P<0.05 compared with respective α-bis doses.

Abbreviations: α-bis, α-bisabolol; α-bis-LNCs, α-bisabolol-loaded lipid-core nanocapsules; LNCs, lipid-core nanocapsules; ULNCs, drug-unloaded nanocapsules; LPS, lipopolysaccharide; SEM, standard error of mean.