Figure 3.

Effect of treatment with α-bis-LNCs on chemokine levels.

Notes: The mice were treated with α-bis, α-bis-LNCs (30, 50, or 100 mg kg⁻¹), or ULNCs 4 hours before LPS or saline instillation. The lungs were perfused and collected to measure levels of (A) KC and (B) MIP-2 by ELISA. Data are expressed as the mean ± SEM (n=5–7). ⁺⁺P<0.01 and ⁺⁺⁺P<0.001 compared with the saline group; **P<0.01 compared with the LPS-induced group; *P<0.05 compared with the LPS-treated group; ^§P<0.05 compared with α-bis.

Abbreviations: α-bis, α-bisabolol; α-bis-LNCs, α-bisabolol-loaded lipid-core nanocapsules; LNCs, lipid-core nanocapsules; ELISA, enzyme-linked immunosorbent assay; ULNCs, drug-unloaded nanocapsules; LPS, lipopolysaccharide; SEM, standard error of mean.