FIG. 9.

Induced seroconversion in 7/16-5 TCR × HBc and HBeAg double-Tg and triple-Tg mice. Groups of three mice each of the indicated double- and triple-Tg strains were injected with the 7/16-5 TCR-specific peptide 129-140 (100 μg) (CFA), and sera were collected at multiple intervals, pooled, and analyzed for IgG anti-HBe and IgG anti-HBc antibodies by ELISA. Antibody titer is defined as the endpoint serum dilution to yield three times the OD₄₉₂ value of equally diluted preimmunization sera. The results are representative of experiments performed on two separate occasions. d, day; WK, week.