TABLE 2.
Summary of HBc/HBeAg-specific TCR-Tg lineages used in this study
| Lineage | Source | T-cell hybridomaa | TCR (Vα/Vβ) | Specificity | TCR+ frequency (splenic CD4+) (%) | Avidity | Toleranceb (dbl-Tgs) |
|---|---|---|---|---|---|---|---|
| 11/4-12 | B10/eAg-Tg | 2B2 | 11.1/4 | 129-140/Ab | 67 | Low | Ignorance |
| 7/16-5 | B10/+ | 4E4 | 5/11 | 129-140/Ab | 53 | Intermediate | Anergy |
| 8/12-2 | B10.S/+ | 1E9 | −/4 | 120-131/As | 37 | High | Deletion (?) |
a
See reference 8 for details of these hybridomas.
b
Determined by breeding TCR-Tg mice with HBV-Tg lineages which express either high or low levels of HBcAg or HBeAg.