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. 2017 Jun 15;23:240–249. doi: 10.12659/MSMBR.904014

Figure 5.

Figure 5

Wnt-β-catenin signaling was involved in STAT6-stimulated macrophages polarization. (A) Expression and quantification of total and nuclear β-catenin in stable and vulnerable plaques (n=5 for each group) and STAT6-overexpressing macrophages. ** P<0.01, compared with HCD or STAT6 vec. (B) Total and nuclear β-catenin levels in macrophages stimulated with IL-4 (10 ng/ml) for 24 h, * P<0.05, ** P<0.01 vs. control. (C) RT-PCR analysis of M2 macrophages markers in β-catenin silencing cells with STAT6 overexpression, ** P<0.01. (D) β-catenin siRNA or control transfected cells were exposed to IL-4 for 24 h, and the mRNA levels of Arg1 and TGF-β were examined using qRT-PCR, ** P<0.01 vs. control, ## P<0.01 vs. IL-4+NC siRNA.