Table 1. Association of human-mouse orthologs with human disease databases.

Listed are the top 10 enriched DAVID terms associated with 827 literature derived mouse atherosclerosis genes. This table shows that genes involved in atherosclerosis in mice also account for CAD and related conditions in humans.

Term	Fold Change	Mouse Genes	FDR*	P-Value**
Coronary artery disease	4.5	53	2.70E-23	1.10E-27
Ischemic heart disease	4.4	32	1.20E-12	5.40E-17
Restenosis	4.3	47	2.90E-19	1.30E-23
Longevity	4	47	8.40E-17	4.90E-21
Coronary atherosclerosis	3.9	100	5.80E-39	3.60E-43
Coronary heart disease	3.9	35	1.40E-11	8.40E-16
Alzheimer’s disease	3.3	89	6.10E-12	3.30E-15
Myocardial infarction	3	62	5.30E-15	5.70E-19
Hypertension	2.6	79	5.40E-15	7.80E-19
Diabetes, type 2	2.1	104	2.00E-13	3.00E-17

^*adjusted for multiple comparison,

^**calculated using Fisher’s exact test.