Table 1.
Characteristics of studies included in the meta-analysis.
| Author | Year | Country | Case | Disease | Method | Cut off value | Endpoints | N OS |
|---|---|---|---|---|---|---|---|---|
| Jiang G20 | 2016 | China | 120 | hepatocellular carcinoma | qRT-PCR | averaged 2−ΔCT value | OS, TTP | 8 |
| Zhou Y21 | 2015 | China | 36 | leiomyosarcoma | IHC | scores of (++) or (+++) | OS, TTP | 8 |
| Li Y22 | 2014 | China | 63 | esophageal squamous cell carcinoma | IHC | positive cells ≥25% and/or scores ≥2 | OS | 6 |
| Zhang X23 | 2013 | China | 118 | non-small cell lung cancer | IHC | score of 3–6 (range of 0–6) | OS | 8 |
| Tian B26 | 2013 | China | 1080 | colorectal cancer | IHC | scored as 1+ or 2+ | OS | 8 |
| Oka S24 | 2012 | Japan | 183 | lung adenocarcinoma | IHC | cellular membrane staining ≥10% | OS | 9 |
| Feng G27 | 2012 | China | 84 | clear cell renal cell carcinoma | qRT-PCR | >0.0362 | TTP | 7 |
| Liu WF28 | 2012 | China | 144 | gastric cancer | IHC | mild staining cells >10% of tumor cells | OS | 6 |
| Wang W13 | 2011 | China | 67 | gallbladder adenocarcinoma | IHC | positive cells ≥25% and/or scores ≥2 | OS | 7 |
| Zabouo G29 | 2009 | France | 635 | breast cancer | IHC | scores of 2+ and 3+ | OS | 8 |
| Aldovini D30 | 2006 | Italy | 126 | epithelial ovarian cancer | IHC | score greater/equal to 2 (range of 0–7) | OS, TTP | 8 |
| Kristiansen G25 | 2003 | Germany | 38 | lung adenocarcinoma | IHC | score of 2+ | OS | 6 |
ICH: Immunohistochemistry; qRT-PCR: quantitative Real-time polymerase chain reaction.