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. 2017 Jun 26;7:4218. doi: 10.1038/s41598-017-04441-x

Figure 6.

Figure 6

Network analysis and force propagation through FLN 16-17. When force is propagated through a molecule, soft degrees of freedom will be stretched out along the path of force propagation, while stiff degrees become more important for the dynamics of the system. Consequently, paths with high correlation of motion describe the paths along which force propagates through the system. (a) The calculated force propagation pathway shows that residue L1788, associated to FMD, is a main node in the force propagation pathway (yellow) in FLNa16-17. The analyses also revealed the strongest correlation between the internal motion of domains 16 and 17 occur between residues Q1857 and T1876. (b) The analyses revealed that in FLNb from LS associated residues G1834 is not part of the force propagation pathway (yellow) while S1902 contributes to the pathway but it is not a main node. (c) Community analysis reveals the highly correlated regions within the protein complex. It shows that L1788 is an important part of one of the network communities in FLNa (marked by the red dashed circle). (d) For FLNb, the mutation sites G1834 and S1902 are not shown as main nodes in the communities.