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. 2017 Jun 26;7:4219. doi: 10.1038/s41598-017-03674-0

Figure 1.

Figure 1

IL-33 potentiates antigen induced inflammation in BALF and airway hyperresponsiveness. (a) Schematic representation of the exposure protocol. Sham-or OVA-sensitized C57BL/6 mice received intranasal instillations of IL-33 or PBS. (b) Total inflammatory cells in BALF were counted. (c) Differential cell counts in BALF were determined. Results expressed as cells/mL for macrophages/monocytes, eosinophils, neutrophils and lymphocytes. (d) Airway hyperresponsiveness (AHR) in response to inhaled methacholine was measured in sham- or OVA-sensitized C57BL/6 mice that received intranasal instillations of IL-33 or PBS. Maximal responses to increasing doses of methacholine are shown for newtonian resistance (Rn), tissue damping (G) and tissue elastance (H) (b–d) *p < 0.05, **p < 0.01, ***p < 0.001 (ANOVA, Bonferroni). Results are pooled data from four independent experiments (mean ± SEM of n = 9–10 mice for each group).