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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Semin Cell Dev Biol. 2017 Jan 16;67:48–55. doi: 10.1016/j.semcdb.2017.01.002

Figure 1.

Figure 1

(A) EVs generated by cancer cells contain a variety of cargo (i.e., protein, RNA, and DNA) that can be transferred to other cells. This causes the phenotypes of recipient cells to change (denoted by the color change) in ways that promote cancer progression. (B) EVs derived from bone marrow or different types of cancer cells accumulate in specific organs in animal models. For example, EVs generated by bone marrow cells accumulate in the kidney where they promote injury recovery (grey arrow and EVs). However, cancer-derived EVs appear to promote metastasis in a variety of organs. Specifically, EVs from melanoma cells preferentially accumulate in the bone, liver, spleen, and lung (green arrows and EVs), EVs from breast cancer cells accumulate in the liver and lungs (pink arrows and EVs), and EVs from pancreatic cancer cells accumulate in the liver, lung, and lymph nodes (blue arrows and EVs).