Table 1.

Clinical disease parameters associated with RNASET2 risk variants.

Clinical parameter		rs1819333		rs9355610
		p	OR	p	OR
Disease Behavior
B2 vs. B1a		ns	ns	0.041	1.07
B3 vs. B1a		ns	ns	0.056	1.06
B2, B3 vs. B1a		0.051	1.05	0.016	1.07
Therapeutic failure of thiopurineb		0.009	1.68	0.019	1.75
Therapeutic failure of anti-TNFb		0.039	1.46	0.042	1.56
ANCA sero-positivityb		0.009	2.24	0.047	2.07
Resected segment	>30 cmb	ns	ns	0.004	2.13
	>40 cmb	ns	ns	0.031	1.96
Endoscopic recurrence		p	z score	p	z score
Rutgeert’s score 3–4 vs 1–2		0.025	2.24	0.024	2.25

^aIIBDGC cohort CD (B1 = 6278, B2 = 3345, B3 = 3828)

^bCD patients (n=584) who had undergone surgical resection and followed prospectively.