Table 3.
Patterns of Oxygenation during the First Three Days of Life as a Predictor of Mortality at 90 days
| No. of Infants | 90 Day Survival | HR (95% CI) | P Value¥ | ||
|---|---|---|---|---|---|
| Median SpO2 | |||||
| AGA >92% | 715 | 90.8 | 1 | ||
| SGA >92% | 42 | 83.3 | 1.8 (.8, 4.0) | 0.1291 | |
| AGA ≤92% | 262 | 83.2 | 1.9 (1.2, 2.8) | 0.0013 | |
| SGA ≤92% | 35 | 54.3 | 6.1 (3.5, 10.4) | <.0001 | |
| P (interaction) | 0.2541 | ||||
| Time <80% | |||||
| AGA <3.2% | 742 | 88.7 | 1 | ||
| SGA <3.2% | 49 | 75.5 | 2.3 (1.3, 4.3) | 0.0077 | |
| AGA ≥3.2% | 235 | 88.9 | 0.98 (.6, 1.5) | 0.9218 | |
| SGA ≥3.2% | 28 | 60.7 | 3.9 (2.1, 7.2) | <.0001 | |
| P (interaction) | 0.2543 | ||||
| Short IH* | |||||
| AGA <14.7/day | 733 | 88.8 | 1 | ||
| SGA <14.7/day | 58 | 77.6 | 2.1 (1.2, 3.7) | 0.0142 | |
| AGA ≥14.7/day | 244 | 88.5 | 1.0 (.6, 1.6) | 0.8994 | |
| SGA ≥14.7/day | 19 | 47.4 | 6.1 (3.2, 11.8) | <.0001 | |
| P (interaction) | 0.0255 | ||||
| Long IH* | |||||
| AGA <12/day | 745 | 88.3 | 1 | ||
| SGA <12/day | 46 | 76.1 | 2.2 (1.2, 4.3) | 0.0162 | |
| AGA ≥12/day | 232 | 90.1 | 0.8 (.5, 1.3) | 0.4549 | |
| SGA ≥12/day | 31 | 61.3 | 3.6 (2.0, 6.3) | <.0001 | |
| P (interaction) | 0.1747 |
*
Short: 20sec–1min, Long: 1–5min
¥
vs Highest Median SpO2 quartile (AGA>92%) or lowest quartile for time <80% (AGA<3.2%), short IH (AGA<14.7/day) and long IH (AGA <12/day)
There were no statistically significant differences in gestational age, race, gender, multiple births, or early sepsis between infant groups. Therefore, unadjusted hazard ratios are presented.