Table 3.

Summary of the effects of cocoa diet in specific antibodies in rat models of arthritis and allergy.

Model	Strain	Cocoa dose	Results	Reference
Adjuvant arthritis	Wistar	5% in the food	↓Specific antibodies	(86)
		10% in the food	↓Specific antibodies
Collagen-induced arthritis	Louvain	5–10% in the food	=Specific IgG1	(32)
			↓Specific IgG2a, IgG2b, IgG2c
Allergy induced by intraperitoneal route	Brown Norway	10% in the food	↓Specific IgG1, IgG2a	(22)
			=Specific IgG2b
			↓Specific IgE
Food allergy induced by intraperitoneal and oral routes	Brown Norway	10% in the food	↓ specific IgG1, IgG2a	(101)
			=Specific IgG2b
			↓Specific IgE
Oral sensitization	Lewis	10% in the food	↓Specific IgG1, IgG2b	(31)
			↓Specific IgM

Ig, immunoglobulin.

Arrows indicate increases or decreases, equals sign means no changes.