Figure 2.

Effect of glucocorticoids on lipolysis and glucose kinetics in vivo. Data are given as mean ± SEM for n = 10 for low insulin (comprising low glucocorticoid [GC] phase [white columns], medium GC [grey columns] and high GC [black columns]) and high insulin (low GC [striped columns], medium GC [checked columns] and high GC [bricked columns]) groups. A, High GC increased the rate of appearance of glycerol in the high insulin group at steady state (t + 180‐240 minutes) and during adrenaline infusion (t + 285‐345 minutes). B, High GC increased NEFA concentrations in the high insulin group during steady state and in both insulin groups during adrenaline infusion. High insulin suppressed the rate of appearance of glycerol and NEFAs (both P < .001). GC phase did not alter either C, endogenous glucose production or D, glucose disposal. Glucose disposal was increased in the high insulin group during steady state (P < .01) but not during adrenaline infusion. Adrenaline decreased glucose disposal in both groups (P < .01). *P < .05 vs low GC, #P < .05 vs medium GC