Table 2.
Genotype and Allele Frequencies of TP53 G72C Polymorphism and Its Genetic Association Between Cervical Carcinoma Patients Compared With Control Subjects Without Cancers and Between HPV‐Positive and HPV‐Negative Patients
| Genotype, Allele | Cases, n (%) | Controls, n (%) | OR (95% CI) | P | HWE Test, Expected Genotypes | |
|---|---|---|---|---|---|---|
| Cases | Controls | |||||
| Cancer (n = 232) | Volunteers (n = 313) | |||||
| G/G | 47 (20) | 64 (20) | 51.21 | 76.26 | ||
| G/C | 124 (53) | 181 (58) | 0.93 (0.60‐1.44) | .757 | 115.58 | 156.47 |
| C/C | 61 (26) | 68 (22) | 1.22 (0.73‐2.03) | .442 | 65.21 | 80.26 |
| G | 218 (47) | 309 (49) | — | — | — | — |
| C | 246 (53) | 317 (51) | 1.10 (0.86‐1.39) | .437 | — | — |
| P = .267 | P = .005 | |||||
| HPV+ (n = 163) | HPV− (n = 50) | |||||
| G/G | 40 (25) | 7 (14) | — | — | 45.37 | 7.61 |
| G/C | 92 (56) | 25 (50) | 0.64 (0.25‐1.61) | .344 | 81.25 | 23.79 |
| C/C | 31 (19) | 18 (36) | 0.30 (0.11‐0.81) | .014 | 36.37 | 18.61 |
| G | 172 (53) | 39 (39) | — | — | — | — |
| C | 154 (47) | 61 (61) | 0.57 (0.36‐0.90) | .016 | — | — |
| P = .091 | P = .719 | |||||
Abbreviations: C, cytosine; CI, confidence interval; G, guanine; HPV+, human papillomavirus–positive; HPV−, human papillomavirus–negative; HWE, Hardy‐Weinberg equilibrium; OR, odds ratio.