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miR‐155 can inhibit MMP‐16 by directly targeting its 3′‐UTRs. Complementarity was observed between miR‐155 and the putative mmuMMP‐16 3′‐UTR target site. mmuMMP‐16 mut indicates the MMP‐16 mRNA 3′‐UTRs with four consecutive mutation sites in miR‐155 binding sites. The relative luciferase activities show the mmuMMP‐16 3′‐UTR 3,055–3,062 bp site, rather than the mmuMMP‐16 3′‐UTR 3,907–3,913 bp site, and is the binding site of miR‐155. n = 3 per group. Data are means ± SD. **p < 0.01.
