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. 2017 Apr 24;35(6):1323–1334. doi: 10.1002/jor.23313

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© 2017 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Assessment of the impact on aggrecan. (A) IHC for aggrecan in each group shows the up‐regulation of miR‐155 can enhance the expression of aggrecan while the down‐regulation of miR‐155 can inhibit the expression at 12 weeks after surgery. Scale bars, 40 µm. n = 5 per group. Data are means ± SD. **p < 0.01. (B) Western blot analysis shows that the expression of aggrecan in each punctured group continued to decrease with time at 3, 6, and 12 weeks after surgery compared with the sham group. The signal of aggrecan in the miR‐up group was higher than that in the puncture group at 3, 6, and 12 weeks, while the signal in the miR‐down group was lower. The signals in the puncture group, miR‐up vector group, and miR‐down vector group were at the same level. n = 5 per group. Data are means ± SD. **p < 0.01.