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. 2017 Apr 24;35(6):1323–1334. doi: 10.1002/jor.23313

Figure 7.

Figure 7

Assessment of the impact on collagen type II. (A) IHC of collagen type II in each group shows that the up‐regulation of miR‐155 can enhance the expression of collagen type II, while the down‐regulation of miR‐155 can inhibit the expression at 12 weeks after surgery. Scale bars, 40 µm. n = 5 per group. Data are means ± SD. **p < 0.01. (B) Western blot analysis shows that the expression of collagen type II in each puncture group continued to decrease with time at 3, 6, 12 weeks after surgery compared with the sham group. The signal of aggrecan in the miR‐up group was higher than that in the puncture group at 3, 6, and 12 weeks, while the signal in the miR‐down group was lower. The signals in the puncture group, miR‐up vector group, and miR‐down vector group were at the same level. n = 5 per group. Data are means ± SD. **p < 0.01.