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. 2017 Mar 15;26(11):2880–2894. doi: 10.1111/mec.14066

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© 2017 The Authors. Molecular Ecology Published by John Wiley & Sons Ltd

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Scan for allele frequency divergence across the Plasmodium falciparum genome between Mauritania (65 clinical isolates) and a more highly endemic population in Guinea (105 clinical isolates), as measured by F_ST with 69 913 SNPs genomewide. The mean genomewide F_ST was 0.004, but nine SNPs had F_ST values >0.2, clustered in 4 loci (labelled a to d) on chromosomes 4, 5, 7 and 8: (a) one SNP on chromosome (chr) 4 within the Rh1 gene (PF3D7_0402300; SNP position 138308, nonsynonymous E191K), (b) one SNP on chr 5 located 4.1 kb from the drug resistance gene mdr1, (c) 5 SNPs on chr 7 located 2.8–8.9 kb from the drug resistance gene crt, (d) two SNPs 3.7 kb apart on chr 8 with one in the drug resistance gene dhps (PF3D7_0810800; SNP position 549 685, nonsynonymous codon G437A having a known role in conferring resistance to sulfadoxine).