Table 2.
Tolerability Assessment of Toxicity by Interviewed Patients
| AE | Acceptable, No. (%) | Slightly Unacceptable, No. (%) | Unacceptable, No. (%) | Totally Unacceptable, No. (%) |
|---|---|---|---|---|
| Alopecia | ||||
| Limited | 38 (63) | 20 (33) | 2 (3) | 0 (0) |
| Important | 20 (33) | 27 (45) | 9 (15) | 4 (7) |
| Anorexia | ||||
| Habitual nutrition | ||||
| 1‐7 d/mo | 52 (88) | 3 (5) | 4 (7) | 0 (0) |
| 8‐14 d/mo | 46 (78) | 9 (15) | 3 (5) | 1 (2) |
| >15 d/mo | 30 (51) | 19 (32) | 9 (15) | 1 (2) |
| Decreased nutrition | ||||
| 1‐7 d/mo | 52 (87) | 4 (7) | 3 (5) | 1 (2) |
| 8‐14 d/mo | 43 (72) | 12 (20) | 4 (7) | 1 (2) |
| >15 d/mo | 28 (47) | 18 (30) | 12 (20) | 2 (3) |
| Decreased nutrition + weight loss | ||||
| 1‐7 d/mo | 38 (63) | 12 (20) | 6 (10) | 4 (7) |
| 8‐14 d/mo | 20 (33) | 25 (42) | 11 (18) | 4 (7) |
| >15 d/mo | 10 (17) | 20 (33) | 21 (35) | 9 (15) |
| Hospitalization | ||||
| 1‐7 d/mo | 23 (38) | 18 (30) | 15 (25) | 4 (7) |
| 8‐14 d/mo | 11 (18) | 17 (28) | 24 (40) | 8 (13) |
| >15 d/mo | 5 (8) | 7 (12) | 31 (52) | 17 (28) |
| Diarrhea | ||||
| Feces increase 1‐3 times/d | ||||
| 1‐7 d/mo | 40 (67) | 18 (30) | 2 (3) | 0 (0) |
| 8‐14 d/mo | 30 (50) | 18 (30) | 12 (20) | 0 (0) |
| >15 d/mo | 21 (35) | 12 (20) | 26 (43) | 1 (2) |
| Feces increase 4‐6 times/d | ||||
| 1‐7 d/mo | 23 (38) | 15 (25) | 17 (28) | 5 (8) |
| 8‐14 d/mo | 7 (12) | 24 (41) | 18 (31) | 10 (17) |
| >15 d/mo | 6 (10) | 10 (17) | 26 (44) | 17 (29) |
| Feces increase ≥ 7 times/d | ||||
| 1‐7 d/mo | 6 (10) | 17 (29) | 17 (29) | 19 (32) |
| 8‐14 d/mo | 3 (5) | 6 (10) | 25 (42) | 25 (42) |
| >15 d/mo | 3 (5) | 5 (8) | 24 (41) | 27 (46) |
| Incontinence | ||||
| 1‐7 d/mo | 6 (10) | 16 (27) | 21 (36) | 16 (27) |
| 8‐14 d/mo | 5 (8) | 3 (5) | 29 (49) | 22 (37) |
| >15 d/mo | 4 (7) | 3 (5) | 25 (42) | 27 (46) |
| Hospitalization | ||||
| 1‐7 d/mo | 27 (46) | 18 (31) | 8 (14) | 6 (10) |
| 8‐14 d/mo | 10 (17) | 15 (25) | 22 (37) | 12 (20) |
| >15 d/mo | 5 (8) | 5 (8) | 29 (49) | 20 (34) |
| Mucositis | ||||
| Slightly painful | ||||
| 1‐7 d/mo | 51 (85) | 7 (12) | 2 (3) | 0 (0) |
| 8‐14 d/mo | 44 (75) | 9 (15) | 5 (8) | 1 (2) |
| >15 d/mo | 36 (61) | 11 (19) | 9 (15) | 3 (5) |
| Moderately painful | ||||
| 1‐7 d/mo | 39 (66) | 13 (22) | 6 (10) | 1 (2) |
| 8‐14 d/mo | 24 (41) | 17 (29) | 16 (27) | 2 (3) |
| >15 d/mo | 18 (31) | 11 (19) | 23 (39) | 7 (12) |
| Painful | ||||
| 1‐7 d/mo | 13 (22) | 16 (27) | 17 (29) | 13 (22) |
| 8‐14 d/mo | 5 (8) | 5 (8) | 28 (47) | 21 (36) |
| >15 d/mo | 4 (7) | 1 (2) | 29 (49) | 25 (42) |
| Hospitalization | ||||
| 1‐7 d/mo | 32 (55) | 10 (17) | 11 (19) | 5 (9) |
| 8‐14 d/mo | 9 (16) | 15 (26) | 24 (41) | 10 (17) |
| >15 d/mo | 7 (12) | 2 (3) | 34 (59) | 15 (26) |
| Hand‐foot skin reaction | ||||
| Slightly painful | ||||
| 1‐7 d/mo | 51 (86) | 6 (10) | 1 (2) | 1 (2) |
| 8‐14 d/mo | 44 (75) | 10 (17) | 4 (7) | 1 (2) |
| >15 d/mo | 38 (64) | 11 (19) | 7 (12) | 3 (5) |
| Moderately painful | ||||
| 1‐7 d/mo | 28 (47) | 20 (34) | 6 (10) | 5 (8) |
| 8‐14 d/mo | 9 (15) | 23 (39) | 15 (25) | 12 (20) |
| ≥15 d/mo | 4 (7) | 11 (19) | 28 (47) | 16 (27) |
| Painful | ||||
| 1‐7 d/mo | 7 (12) | 10 (17) | 23 (39) | 19 (32) |
| 8‐14 d/mo | 2 (3) | 2 (3) | 31 (53) | 24 (41) |
| ≥15 d/mo | 2 (3) | 1 (2) | 31 (53) | 25 (42) |
| Hospitalization | ||||
| 1‐7 d/mo | 30 (51) | 14 (24) | 7 (12) | 8 (14) |
| 8‐14 d/mo | 11 (19) | 15 (25) | 19 (32) | 14 (24) |
| ≥15 d/mo | 6 (10) | 7 (12) | 27 (46) | 19 (32) |
| Arterial hypertension | ||||
| Without treatment | ||||
| 1‐7 d/mo | 56 (93) | 2 (3) | 2 (3) | 0 (0) |
| 8‐14 d/mo | 55 (92) | 2 (3) | 3 (5) | 0 (0) |
| ≥15 d/mo | 53 (88) | 4 (7) | 3 (5) | 0 (0) |
| With 1 more treatment/d | ||||
| 1‐7 d/mo | 52 (87) | 4 (7) | 4 (7) | 0 (0) |
| 8‐14 d/mo | 51 (85) | 5 (8) | 4 (7) | 0 (0) |
| ≥15 d/mo | 49 (82) | 7 (12) | 4 (7) | 0 (0) |
| With 2 or 3 more treatments/d | ||||
| 1‐7 d/mo | 38 (63) | 12 (20) | 9 (15) | 1 (2) |
| 8‐14 d/mo | 32 (53) | 15 (25) | 11 (18) | 2 (3) |
| ≥15 d/mo | 30 (50) | 16 (27) | 11 (18) | 3 (5) |
| Hospitalization | ||||
| 1‐7 d/mo | 35 (59) | 9 (15) | 11 (19) | 4 (7) |
| 8‐14 d/mo | 14 (24) | 11 (19) | 23 (39) | 11 (19) |
| ≥15 d/mo | 8 (14) | 7 (12) | 29 (49) | 15 (25) |
| Asthenia | ||||
| Without modification of activities | ||||
| 1‐7 d/mo | 43 (93) | 2 (4) | 1 (2) | 0 (0) |
| 8‐14 d/mo | 40 (87) | 3 (7) | 2 (4) | 1 (2) |
| ≥15 d/mo | 34 (74) | 5 (11) | 5 (11) | 2 (4) |
| Need rest at least half‐d/d | ||||
| 1‐7 d/mo | 38 (83) | 6 (13) | 2 (4) | 0 (0) |
| 8‐14 d/mo | 29 (63) | 13 (28) | 3 (7) | 1 (2) |
| ≥15 d/mo | 19 (41) | 15 (33) | 8 (17) | 4 (9) |
| Need rest more than half‐d/d | ||||
| 1‐7 d/mo | 25 (54) | 10 (22) | 7 (15) | 4 (9) |
| 8‐14 d/mo | 9 (20) | 20 (43) | 10 (22) | 7 (15) |
| ≥15 d/mo | 4 (9) | 10 (22) | 19 (41) | 13 (28) |
| Hospitalization | ||||
| 1‐7 d/mo | 27 (59) | 8 (17) | 7 (15) | 4 (9) |
| 8‐14 d/mo | 8 (17) | 17 (37) | 11 (24) | 10 (22) |
| ≥15 d/mo | 5 (11) | 3 (7) | 23 (50) | 15 (33) |