Table 2.

Number of LDN dispenses and average amount (DDD) of opioids (ATC N02A) dispensed 1 year before and 1 year after the first LDN prescription in 2013 in Norway. Mean paired differences with 95% confidence intervals (CI), and p‐value for paired t‐test

Number of LDN dispenses (subgroup)	N	Opioids before	Opioids after	Mean paired difference		95% CI of difference (DDD)	p
		(DDD)	(DDD)	(DDD)	(%)
LDN × 1	1347	112.3	107.3	−5.0	−4.4	−11.3 to 1.4	0.123
LDN × 2–3	1152	79.5	67.4	−12.1	−15.2	−17.1 to −7.0	<0.001
LDN ≥ 4	1276	90.1	49.0	−41.1	−45.7	−47.1 to −35.1	<0.001
Any LDN	3775	94.8	75.4	−19.4	−20.4	−22.8 to −15.9	<0.001