Table 3.
Levels of pro-MMP-9 and TIMP-1, and pro-MMP-9 / TIMP-1 ratio in BAL supernatant fluids, recovered from p47phox +/+ [WT] and p47phox -/- [KO] mice, 1 day or 14 days after intranasal administration of bleomycin (BLM, 0.1 mg/mouse) or saline vehicle (Control, NaCl 0.9%). For Pro-MMP-9 and TIMP-1, results are represented as the mean (pg/ml) ± SEM. N : number of mice. a : P < 0.05, b : P < 0.01, in comparison to control mice exposed to saline solution only. * : P < 0.05, ** : P < 0.01, for [KO] mice in comparison to [WT] mice.
| Treatment | Strain | N | Pro-MMP-9 | TIMP-1 | Ratio Pro-MMP-9 / TIMP-1 |
| Control | [WT] | 5 | 46.3 ± 14.9 | 38.7 ± 13.5 | 2.7 ± 1.3 |
| [KO] | 5 | 1314.7 ± 798.2 ** | 325.2 ± 173.6 | 10.4 ± 4.7 | |
| BLM, day 1 | [WT] | 7 | 2645.9 ± 1 011.6 b | 781.8 ± 158.9 b | 3.8 ± 1.3 |
| [KO] | 8 | 23646.8 ± 2 359.7 b, ** | 1 213.8 ± 396.4 | 60.8 ± 23.7 a, ** | |
| BLM, day 14 | [WT] | 7 | 37.7 ± 9.1 | 2693.3 ± 378.3 b | 0.02 ± 0.00 b |
| [KO] | 6 | 137.9 ± 15.5 b | 567.9 ± 163.5** | 0.2 ± 0.1 b, ** | |