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. 2017 Jan 23;36(24):3450–3463. doi: 10.1038/onc.2016.495

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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VHL modulates AURKA protein levels. (a) Lysates from 786-0 to isogenic 786-0 cells overexpressing VHL (VHL₂₄) cultured at sub-confluent (cycling) or confluent and serum starved conditions (48 h) probed as indicated. (b) Densitometric quantitation of the average ratio of AURKA to tubulin expression from 786-0 (black bars) to 786-0 VHL₂₄ (gray bars) cells. *P<0.01. (c) Lysates harvested from 786-0 to 786-0 VHL₂₄ cells cultured to confluence and serum starved for 24 h before treatment with CHX for the indicated time points probed as shown. (d) Densitometric quantitation showing an average ratio of AURKA to tubulin in 786-0 (black bars) and 786-0 VHL₂₄ (gray bars) cells treated with CHX. *P<0.01. ^# Denotes significant differences exclusively in the 786-0 VHL₂₄ cell line at the each of the indicated CHX treatment time points compared with the 0- h time point (P<0.05). Error bars denote s.e.m.