Figure 2.

Effect of ADAMTS5 deficiency on BAT activity in obese mice. (A) Locomotive activity during light and dark phase of obese wild-type (white bars; +/+; n = 13) and Adamts5^−/− (black bars; -/-; n = 10) mice kept in Calocages. (B,C) Energy expenditure (B) and heat production (C) measured over a 24 h period. (D–F) Ex vivo¹⁸F-FDG distribution analysis for percentage injected dose per gram (ID/g) (D), mean standardized uptake value (SUV) (E), and total lesion glycolysis (TLG) (F) in isolated interscapular BAT and inguinal SC AT of obese Adamts5^+/+ and Adamts5^−/− mice (n = 6). Data are means ± SEM of n determinations. *p < 0.05 versus wild-type.