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. 2017 May 4;6(7):640–650. doi: 10.1016/j.molmet.2017.04.009

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Rock inhibitors Fasudil and RKI-1447 induce pancreatic progenitor differentiation. (A) Schematic representation of the experimental procedure for pancreatic differentiation. (B–C) Fasudil and RKI-1447 induced DE successfully differentiates into PDX1 and FOXA2 pancreatic progenitors. (D) Liver progenitor markers, AFP, TTR expression is significantly reduced in Fasudil treated cells compared to WNT3A/AA treatment. (E–H) Individual FACS profiles of the cells treated with WNT3A/AA, Fasudil and RKI-1447. (I) FACS plots comparing the differentiation efficiencies towards the PDX1; Fasudil (green) RKI-1447 (blue) and WNT3A/AA (orange) mean ± SDV, ***P < 0.0005.