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. 2017 May 19;6(7):651–663. doi: 10.1016/j.molmet.2017.05.005

Figure 7.

Figure 7

Silencing of TFB2M in insulin-producing cells results in increased activation of apoptosis via the mitochondrial-dependent pathway. (A) Western blot and densitometry analysis of BAX and Cleaved-caspase 3 protein abundance in control and TFB2M-deficient INS-1 832/13 clonal cells; n = 5 different cell passages/group. (B) Western blot and densitometry analysis of AKT, phospho-AKT (Ser 473), and BCL-2 protein abundance in control and TFB2M-deficient INS-1 832/13 clonal cells; n = 5 different cell passages/group. Representative images for quantitative western blots are shown. Statistical differences were examined by unpaired Student's t-test. *P < 0.05 and **P < 0.01 versus the corresponding value for controls.