A simplified scheme of the interlinked neuronal circuits implicated in the regulation of feeding, reward, and stress. The scheme selectively highlights the interaction discussed in regard to anorexia nervosa and the activity-based anorexia rodent model. 5-HT, serotonin; ACTH, adrenocorticotropin; AgRP, agouti-related protein; ARC, arcuate nucleus (hypothalamus); BNST, bed nucleus (stria terminalis); CeA, central amygdala; CORT, corticosterone; CRH, corticotrophin-releasing hormone; DA, dopamine; LH, lateral hypothalamus; MC4R, melanocortin 4 receptors; MCH, melanin-concentrating hormone; NAc, nucleus accumbens; POMC, pro-opiomelanocortin; PVN, paraventricular hypothalamus; VTA, ventral tegmental area.