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Schematic model of miR-200c accelerating hepatic stellate cell-induced liver fibrosis via targeting the FOG2/PI3K pathway. miR-200c activates HSCs and finally accelerates the progression of liver fibrosis via downregulation of FOG2 protein synthesis, activation of PI3K/Akt signaling. Autocrine activation of EGF signaling may also be a mechanism of miR-200c-mediated HSCs activation.
