Table 1.
Associations between seven SNPs in the miR-10b gene and breast cancer risk.
| SNP | Chr | Position | Location | Allelesa | Casesb N = 1,064 |
Controlsb N = 1,073 |
Call rate (%) | MAFc (case/control) |
HWEd | OR (95% CI)e | P valuee |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs4078756 | 2q31.1 | 177,004,115 | 11 kb upstream of pre-mir-10b | A/G | 540/436/84 | 582/425/66 | 97.80 | 0.285/0.260 | 0.341 | 1.17 (1.02–1.35) | 0.027 |
| rs1348807 | 2q31.1 | 177,005,757 | 9.3 kb upstream of pre-mir-10b | A/G | 403/499/156 | 391/507/171 | 97.52 | 0.383/0.398 | 0.750 | 0.91 (0.80–1.03) | 0.148 |
| rs10188827 | 2q31.1 | 177,007,664 | 7.5 kb upstream of pre-mir-10b | A/G | 514/448/99 | 502/471/99 | 97.85 | 0.304/0.312 | 0.477 | 0.92 (0.80–1.05) | 0.210 |
| rs6736786 | 2q31.1 | 177,008,914 | 6 kb upstream of pre-mir-10b | A/G | 419/495/148 | 446/495/132 | 97.89 | 0.372/0.354 | 0.79 | 1.13 (0.99–1.29) | 0.066 |
| rs10196832 | 2q31.1 | 177,011,655 | 3.5 kb upstream of pre-mir-10b | A/G | 936/127/1 | 920/143/7 | 97.89 | 0.061/0.073 | 0.502 | 0.87 (0.68–1.12) | 0.281 |
| rs4972806 | 2q31.1 | 177,012,578 | 2.5 kb upstream of pre-mir-10b | A/G | 352/512/197 | 361/529/183 | 97.85 | 0.427/0.417 | 0.706 | 1.03 (0.91–1.17) | 0.643 |
| rs1867863 | 2q31.1 | 177,014,970 | 161 bp upstream of pre-mir-10b | A/C | 434/488/140 | 403/519/151 | 97.89 | 0.362/0.383 | 0.477 | 0.90 (0.79–1.02) | 0.105 |
aMajor/minor allele; bmajor homozygote/heterozygote/rare homozygote between cases and controls; cminor allele frequency (MAF); dPvalues for the Hardy-Weinberger equilibrium (HWE) test; elogistic regression analysis with adjustment for age, age at menarche, and menopausal status in the additive model; Chr: chromosome, OR: odds ratio, CI: confidence interval.