Table 2.
Associations between rs4078756 in the promoter region of miR-10b and breast cancer risk.
| Characteristics | Cases | Controls | OR (95% CI)a | P | P b | ||||
|---|---|---|---|---|---|---|---|---|---|
| AA (%) | AG (%) | GG (%) | AA (%) | AG (%) | GG (%) | ||||
| Age | |||||||||
| <51 years | 312 (53.0) | 242 (41.1) | 35 (5.9) | 289 (53.3) | 226 (41.7) | 27 (5.0) | 1.05 (0.86–1.28) | 0.648 | 0.111 |
| ≥51 years | 228 (48.4) | 194 (41.2) | 49 (10.4) | 293 (55.2) | 199 (37.5) | 39 (7.3) | 1.32 (1.08–1.61) | 0.007 | |
| Menopausal status | |||||||||
| Premenopausal | 266 (51.9) | 211 (41.1) | 36 (7.0) | 267 (53.0) | 212 (42.1) | 25 (5.0) | 1.15 (0.93–1.42) | 0.197 | 0.540 |
| Postmenopausal | 217 (48.2) | 194 (43.1) | 39 (8.7) | 286 (54.5) | 201 (38.3) | 38 (7.2) | 1.26 (1.03–1.54) | 0.028 | |
| Age at menarche | |||||||||
| <16 years | 320 (53.5) | 236 (39.5) | 42 (7.0) | 217 (52.8) | 172 (41.9) | 22 (5.4) | 1.03 (0.84–1.26) | 0.799 | 0.115 |
| ≥16 years | 211 (47.5) | 192 (43.2) | 41 (9.2) | 363 (55.0) | 253 (38.3) | 44 (6.7) | 1.29 (1.06–1.56) | 0.010 | |
| Age at first live birth | |||||||||
| <24 years | 119 (49.6) | 104 (43.3) | 17 (7.1) | 204 (55.0) | 140 (37.7) | 27 (7.3) | 1.18 (0.90–1.53) | 0.229 | 0.831 |
| ≥24 years | 392 (52.0) | 301 (39.9) | 61 (8.1) | 358 (53.4) | 276 (41.1) | 37 (5.5) | 1.14 (0.96–1.36) | 0.141 | |
| ER status | |||||||||
| Positive | 237 (48.6) | 211 (43.2) | 40 (8.2) | 1.27 (1.07–1.52) | 0.008 | 0.713 | |||
| Negative | 194 (51.5) | 146 (38.7) | 37 (9.8) | 1.21 (1.0–1.46) | 0.055 | ||||
| PR status | |||||||||
| Positive | 237 (46.9) | 223 (44.2) | 45 (8.9) | 1.34 (1.12–1.60) | 0.001 | 0.204 | |||
| Negative | 192 (53.3) | 136 (37.8) | 32 (8.9) | 1.13 (0.93–1.37) | 0.235 | ||||
aPer-allele odds ratio (OR) and 95% confidence interval (CI) adjusted for age, age at menarche, and menopausal status where appropriate; bP value for the heterogeneity test; ER: estrogen receptor; PR: progesterone receptor.