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. 2017 May 15;6(7):748–759. doi: 10.1016/j.molmet.2017.05.006

Figure 6.

Figure 6

Sim1Cre deletion of Glp1r attenuates impact of neonatal Ex-4 on adult body weight and WAT browning.Glp1r expression in the hypothalamus in P28 female mice by in situ in Glp1rloxP/loxP (control) and Sim1Cre;Glp1rloxP/loxP mice (A–H). PVH: paraventricular nucleus of the hypothalamus, SON: supraoptic nucleus, DMH: dorsal medial hypothalamus, ARH: arcuate nucleus of the hypothalamus. (Scale Bar 150 μm PVH and ARH, 100 μm SON and DMH). (I–O) Histological analysis of parametrial adipose tissue. Parametrial fat pads from P28 Glp1rloxP/loxP (control) and Sim1Cre;Glp1rloxP/loxP female mice stained with anti-UCP1 and anti-TH (I–M UCP1/TH merge Scale Bar: 10 μm, I′–M′ UCP1, I″–M″ TH, I‴-M‴ merge Scale Bar 2.5 μm). IR of UCP1 and TH in parametrial WAT quantified using ImageJ (N–O). Values are means ± SEM, n = 3–5 mice/group. *p < 0.05 relative to Veh Glp1rloxP/loxP (Two-tailed Student's t test).