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. 2017 Jun 11;2017:3296294. doi: 10.1155/2017/3296294

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Copyright © 2017 Mazhar Pasha et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Protective effects of Sestrins in cardiovascular diseases, metabolic disorders, neurodegenerative diseases, and cancer. The antioxidant effects of Sestrins are primarily responsible for their protective effects against neurodegenerative diseases and other disease states associated with significant accumulation of ROS. Additionally, by modulating mTOR/AMPK signaling pathway by Sestrin2 indirectly represses tumor growth and activates autophagy. Consequently, autophagy activation confers a protective role of metabolic and heart diseases and aging. ATG1/13: autophagy-related protein 1 and 13; mTOR: mammalian target of rapamycin.